Frasier

From Wikipedia:

Frasier is an American sitcom that was broadcast on NBC for eleven seasons, from September 16, 1993 to May 13, 2004. The program was created and produced by David Angell, Peter Casey, and David Lee (as Grub Street Productions) in association with Grammnet (2004) and Paramount Network Television.

A spin-off from Cheers, Frasier stars Kelsey Grammer as psychiatrist Dr. Frasier Crane; David Hyde Pierce, John Mahoney, Jane Leeves, Peri Gilpin, and Moose (later, Enzo; both Jack Russell Terriers, uncredited). It is one of the most successful spin-off series in television history and one of the most critically acclaimed comedy series of all time.

Psychiatrist Dr. Frasier Crane (Grammer) returns to his hometown of Seattle, Washington, following the end of his marriage and his life in Boston (as seen in Cheers). His plans for a new life as a bachelor are complicated when he is obliged to take in his father, retired police officer Martin (Mahoney), who is unable to live by himself after being shot in the line of duty. Frasier and Martin are joined by Daphne Moon (Leeves), Martin's eccentric English live-in physical therapist and caretaker, and Martin's dog Eddie (played by Moose and Enzo). Frasier's younger brother Niles (Pierce), a fellow psychiatrist, frequently visits their apartment. Niles' infatuation with, and eventual love for Daphne—feelings which he does not confess to her openly until the final episode of the seventh season—form a complex story arc that spans the entire series.

Frasier hosts the popular "The Dr. Frasier Crane Show" on the talk radio station KACL. While his producer Roz Doyle (Gilpin) is very different from Frasier in taste and temperament, over time they become very close friends. Frasier and the others often visit the local coffee shop Café Nervosa, the scene of many of their comic adventures.

The sons, who possess fine tastes, intellectual interests, and high opinions of themselves, frequently clash with their blue-collar, down-to-earth father. Frasier and Niles' relationship is often also turbulent; while very close, their intense sibling rivalry frequently results in chaos. Other recurring themes include the breakdown of Niles' marriage to the never-seen Maris, Frasier's search for love in his own life, and the various attempts of the two brothers to gain acceptance into Seattle's cultural elite.