Bosom Buddies is an American sitcom starring Tom Hanks and Peter Scolari created by Robert L. Boyett, Thomas L. Miller and Chris Thompson. It ran from 1980 to 1982 (with 37 episodes total) on ABC and in reruns in the summer of 1984 on NBC.
The series was originally conceived by Miller and Boyett as both a takeoff on the movie Some Like It Hot and a male counterpart to their hit farce show Laverne & Shirley. After the cast had been chosen, Miller and Boyett asked Chris Thompson, one of the writer-producers of Laverne & Shirley, to write the pilot and be the series showrunner. Thompson (who would go on to executive-produce such shows as The Larry Sanders Show), said later that he took the job purely for the money, but unexpectedly found it to be "my completely favorite experience in show business," because the network left him and his young cast free to experiment. "We were left alone," he recalled. "Nobody was paying attention to us. We were all really young, but it was like we had daddy's Porsche. We had $500,000 to play with every week."  The show became known for its quirky humor and its frequent use of improvisation, especially between stars Tom Hanks and Peter Scolari. Though the show started out with good ratings, it failed to hold the public's interest and was canceled after two seasons.
After their own apartment is demolished, two men disguise themselves as women in order to live in the women-only Susan B. Anthony Hotel because of the dirt cheap rent. Kip Wilson (Tom Hanks) is originally skeptical of the plan, but after meeting knock-out resident model/dancer/nurse Sonny Lumet (Donna Dixon), he ends up convincing aspiring writer Henry Desmond (Peter Scolari) that the experience will make a great book. Their co-worker, Amy Cassidy, (Wendie Jo Sperber) is the only resident in on the plan because she's attracted to Henry. In the first season, Kip, Henry, and Amy work for Ruth Dunbar (Holland Taylor) at the advertising firm of Livingston, Gentry & Mishkin, where Kip is a graphic artist, Henry is a copy writer, and Amy is the receptionist. Ruth often takes credit for the boys’ work when reporting to her (unseen) boss, Mr. Rubinowitz.
The boys’ deception includes outwitting the hotel manager, Lily Sinclair (Lucille Benson), and fellow resident, Isabelle Hammond (Telma Hopkins), an aspiring singer.
In the second season, Kip, Henry and Amy leave Livingston, Gentry & Mishkin to start their own advertising firm, Sixty Seconds Street, with Ruth serving as a not-quite silent partner.
In the first episode of the second season, the male characters’ ruse of living in drag is revealed, although they are allowed to continue living at the women-only hotel anyway. Sonny forgives Kip for the deception, and as the new hotel manager replacing Lily, Isabelle agrees to go along with the ruse rather than admit it to the other residents.
* Tom Hanks - Kip Wilson/Buffy (when in drag)
* Peter Scolari - Henry Desmond/Hildegarde (when in drag)
* Wendie Jo Sperber- Amy Cassidy, co-worker and friend who knows their secret
* Holland Taylor - Ruth Dunbar, their boss
* Donna Dixon - Sonny Lumet, Kip’s love interest and hotel resident
* Telma Hopkins - Isabelle Hammond, hotel resident (hotel manager in the second season)
* Lucille Benson - Lilly Sinclair, hotel manager (1980-1981)