From Wikipedia:
The Real McCoys is an American situation comedy co-produced by Danny Thomas's Marterto Productions in association with Walter Brennan and Irving Pincus's Westgate Company. The series aired for six seasons altogether, the first five on the ABC-TV network from 1957 through 1962 and in its final year, 1962 to 1963, on CBS.
Set in the San Fernando Valley of California, the series was filmed in Hollywood at Desilu studios.
The Real McCoys revolves around the lives of a family from the Appalachian Mountains who originally hailed from fictional Smokey Corners, West Virginia. The McCoys moved to California and became dirt farmers. The family consisted of Grandpa Amos McCoy (Walter Brennan); his grandson Luke (Richard Crenna), Luke's new bride Kate (Kathy Nolan), Luke's teenage sister Tallahassie "Hassie" (Lydia Reed), and his 11-year-old brother Little Luke (Michael Winkelman). The double-naming of the brothers was explained in the first episode by the elder Luke: Because their parents were so excited over the birth of the younger boy, "they forgot all about me!" Only Crenna was in every episode.
For its first three seasons, The Real McCoys, which followed The Donna Reed Show, was the lead-in program on the ABC Thursday lineup for The Pat Boone Chevy Showroom, which aired from 1957 to 1960. The Pat Boone series was succeeded in 1960 by Fred MacMurray and William Frawley in My Three Sons.
Although the series had ranked in the Top 10 the entire time it was on ABC, The Real McCoys fell into disfavor after being sold to CBS. It was cancelled in the summer of 1963. Factors in the cancellation were the changes in the series (especially the departure of the character Kate McCoy, played by Kathy Nolan), its new Sunday evening time slot opposite NBC's Bonanza, and CBS's concentration on another rural show, The Beverly Hillbillies, which had become the No. 1 entry on television.