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"When I'm teaching my directing class, I always ask, 'how happy was your childhood? Were your parents always together?' And if they're really happy and their parents are together, I say 'oooh, the odds are going to be against you!' Because part of what being a director is, certainly in television and also in films, is that we try to recreate our families, and we try to perfect them." 

"In the pilot we asked, 'Would you rather have a doctor hold your hand while you die or have a doctor treat you like crap while he cured you?' Humanity to some extent is synonymous with caring. House didn't care about caring. He cared about results."

"The role of music in television, or movies, serves two functions: it deals with tension and release. It has a magical ability to paint the psyche emotionally. We call it sometimes 'emotion lotion,' because it hits you. Nothing hits you harder than music."

"I just knew that there was something unusual about the quality of my voice, and I also really loved to make people laugh. And that was the main thing. It wasn't so much acting as it was saying something that took somebody from just having a hum-ho day to kind of brightening them up a little bit. I liked creating effects that would make people happy."